Evasionofhostimmuneresponses is well documented for viruses and may also occur during tumor immunosurveillance.
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Tumor immuneescape has been a major problem for developing effective immunotherapy.
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Augmenting immune surveillance and suppressing immuneescape are crucial in tumor immunotherapy.
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Recent evidence has revealed that oncogenic mutations may confer immuneescape.
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The HPV protein responsible for inducing this immuneescape has not been determined.
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Secondly, graft failure and the immuneescape of extramedullary plasmocytoma have been reported.
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This is particularly true for HIV, which has developed numerous immuneevasion mechanisms.
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For example, tumor cells have been shown to develop active immuneevasion mechanisms.
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Therefore, viruses have developed mechanisms to target TRIMs for immuneevasion.
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Exhaustion and suppression of antiviral immune responses can result in viral immuneevasion.
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This immuneevasion mechanism imposes limitations on antibody-based vaccination and convalescent serum therapy.
Uso de antigenic escape em inglês
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This finding led us to hypothesize that a conserved structural basis of antigenicescape from anti-AMA-1 exists.
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Here, we describe the evolution of antigenicescape variants in a rhesus macaque that developed unusually high neutralizing antibody titers to SIVmac239.
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By using an in vitro model of antigenicescape, the inhibitory contribution of 24 polymorphic sites of the 3D7 AMA-1 vaccine was determined.